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Honours Projects

Chemistry Honours/Major Research Projects

Supervisor Title/References
Heather Andreas

1.听听 听Improving Supercapacitor performance through:

a.听Indentifying chemical reactions that cause the loss of stored charge.
b.听Improving the surface chemistry of Supercapacitor electrodes.

Andreas, Lussier and Oickle, J. Power Sources 187 (2009) 275鈥283; Black and Andreas, J. Phys. Chem. C 2010, 114, 12030鈥12038.

2.听听听 Using Bovine Serum Albumin as a blocking protein in biosensors.

Yang, Huang, Meng, Shen and听 Jiao , Analytica Chimica Acta 647 (2009) 159鈥166.

Stephen Bearne

1.听听 Strategies of enzyme inhibitor/drug design:听 synthesis and evaluation of enzyme inhibitors

2.听听 Enzyme catalysis:听 Site-directed mutagenesis, covalent modification, and spectroscopic studies to analyze the role of enzyme active site architecture in catalysis

3.听 Chemical biology: design, synthesis, and evaluation of reagents for enzyme activity profiling of proteomes

Lietzan, Nagaar, Pellmann, Bourque, Bearne, & St. Maurice (2012) Biochemistry 51, 1160.

Nagar, Narmandakh, Khalak, & Bearne (2012) Biochemistry 50, 8846. Steeves & Bearne (2011) Bioorg. Med. Chem. Lett. 21, 5188.

Jeff Dahn Small Angle X-ray Scattering Studies of Porous Templated Materials used as Catalyst supports

Garsuch A, d'Eon R, Dahn T, et al., Journal of the Electrochemical Society, 155, B236-B243 (2008)

Mita Dasog Development of materials for energy, optoelectronics, and catalytic applications.

Silicon Nanocrystals and Silicon-Polymer Hybrids: Synthesis, Engineering, and Applications.鈥 M. Dasog, J. Kehrle, B. Rieger and J. G. C. Veinot听 Angew Chem Int Ed Engl. 2016, 2322-39
Alan Doucette Enhanced separation of proteins according to molecular weight
through two-stage multiplexed GELFrEE partitioning

Tran, J; Doucette, A.,听 Anal. Chem, 80, 1568-
1573 (2008).

David Jakeman

1. Chemical biology: discovery of new natural products with cytotoxic activity.

Eight-membered ring-containing jadomycins: implications for non-enzymatic natural products biosynthesis. Robertson, A.W.; Martinez-Farina, C.F.; Smithen, D.A.; Yin, H.; Monro, S.; Thompson, A.; McFarland, S.A.; Syvitski, R.T.; Jakeman,听D.L., J. Am. Chem. Soc. 2015, 137, 3271鈥3275.听http://pubs.acs.org/doi/abs/10.1021/ja5114672

2. Chemical biology: synthesis and evaluation of enzyme inhibitors as potential antibacterials.

伪-Fluorophosphonates reveal how a phosphomutase conserves the protein transition state over hexose recognition in its two-step reaction Jin, Y.; Bhattasali, D.; Pellegrini, E.; Forget, S.M.; Baxter, N.J.; Cliff, M.J.; Bowler, M.W.; Jakeman, D.L.;听Blackburn, G.M.; Waltho, J.P. Proc. Natl. Acad. Sci USA. 2014, 111, 12384-12389.听http://www.pnas.org/content/111/34/12384.long

Erin Johnson

Theoretical chemistry, Computational chemistry, Quantum chemistry, Density functional theory, Molecular interactions, Physical chemistry, Materials

A. Otero de la Roza, B. Huynh Cao, I. K. Price, J. E. Hein, and E. R. Johnson. Predicting the Relative Solubilities of Racemic and Enantiopure Crystals by Density-Functional Theory. Angew. Chem. Int. Ed. 53, 7879-7882 (2014).

听Z. Ye, A. Otero de la Roza, E. R. Johnson, and A. Martini. Oscillatory Motion of Bilayer Graphene. Nanotech. 25, 425703 (2014).

A. Otero de la Roza, J. D. Mallory, and E. R. Johnson. MetallophilicInteractions from Dispersion-Corrected Density-Functional Theory. J. Chem. Phys. 140, 18A504 (2014).

Mark Obrovac Research in nanostructured alloy materials for advanced Li-ion batteries and in new advanced batteries based on sodium and magnesium-ion chemistries.

M.N. Obrovac and V.L. Chevrier, Alloy Negative Electrodes for Li-Ion Batteries, Chemical Reviews, 114 (2014) 11444.

R. Fielden and M. N. Obrovac, Investigation of the NaNixMn1-xO2 (0 鈮 x 鈮 1) System for Na-Ion Battery Cathode Materials, J. Electrochem. Soc., 162 (2015), A453

Jan Rainey听

Spectroscopic characterization, structural biology, simulation and bioinformatic analysis of membrane-spanning and fibrous proteins.

Langelaan, D.N., Reddy, T., Banks, A.W., Dellaire, G., Dupr茅, D.J. and Rainey, J.K. Biochim Biophys Acta, 1828, 1471-1483 (2013).

Reddy, T. and Rainey, J.K. J Phys Chem B, 116. 8942-8954 (2012).

Xu, L., Rainey, J.K., Meng, Q. and Liu, X-Q. PLOS ONE, 7, e50227 (2012).

Alex Speed

1.听听听听 Development of catalytic reactions using听 low valent phosphorous compounds.

2.听听听听 Development of chiral catalysts using combinations of boron and nitrogen.

1)听听 Chong, C. C.; Kinjo, R. Angew. Chem. Int. Ed. 2015, 54, 12116-12120.
2)听听 Hounjet, L. J.; Stephan, D. W. Org. Process Res. Dev., 2014, 18, 385- 391.

Mark Stradiotto

Design and Application of New Transition Metal
Catalysts for use in Chemical Synthesis

Stradiotto and co-workers: Synlett, 2011, 2443 (Review from past 3 years).

Alison Thompson听

Synthesis of heterocycles and other organic and inorganic frameworks - methodology development, materials with new light absorbing/emitting properties, medicinal chemistry to design compounds with biological activity such as anti-malarial and anti-cancer properties.

Conversion of F-BODIPYs to Cl-BODIPYs: Enhancing the Reactivity of F-BODIPYs. Lundrigan, T.; Thompson, A. J. Org. Chem. 2013, 78, 757-761.

Influence of B-ring modifications on proton affinity, transmembrane anion transport and anti-cancer properties of synthetic prodigiosenes. Marchal, E.; Rastogi, S.; Thompson, A.; Davis, J.T. Org. Biomol. Chem., 2014, 12, 7515-7522听

Activation and Deprotection of F-BODIPYs using Boron Trihalides. Lundrigan, T.; Cameron, T.S.; Thompson, A. Chem. Commun. 2014, 50, 7028-7031听

Laura Turculet

Transition metal pincer complexes: Synthesis, bond activation chemistry,and catalysis

Morgan, E; MacLean, D. F.; McDonald, R.; Turculet, L. J. Am. Chem. Soc., 2009, 132, 14234.

Mitton, S. J.; Turculet, L. Chem. Eur. J., 2012, 18, 15258.

Peng Zhang

Synthesis of nano-materials for potential biomedical and energy-related applications.听

Impact of Protecting Ligands on Surface Structure and Antibacterial Activity of Silver听Nanoparticles,听 J. Daniel Padmos, Robert T. M. Boudreau, Donald F. Weaver and Peng Zhang,听Langmuir听2015, 31, 3745

Correlating the Atomic Structure of Bimetallic听Silver-Gold Nanoparticles to Their Antibacterial and Cytotoxic Activities, J. Daniel Padmos, Maxine Langman, Katelyn MacDonald, Patricia Comeau, Zhan Yang, Mark Filliagi and Peng Zhang,听J. Phys. Chem. C2015, 119, 7472

Josef Zwanziger Optical properties of lead-free glass

M. Guignard, L. Albrecht, J. W. Zwanziger, Chemistry of Materials, 19, 286-290 (2007).
M. Guignard, J. W. Zwanziger, J. Non-Cryst. Solids, 354, 79-83 (2008).